@article {SADOWSKA:November 2006:1323-7799:741, author = "SADOWSKA, AnnaM.", author = "LUYTEN, Chris", author = "VINTS, Anne-Marie", author = "VERBRAECKEN, Johan", author = "RANST, DirkVan", author = "BACKER, WilfriedA. De", title = "Systemic antioxidant defences during acute exacerbation of chronic obstructive pulmonary disease", journal = "Respirology", volume = "11", year = "November 2006", abstract = "Systemic antioxidant defences during acute exacerbation of chronic obstructive pulmonary disease

SADOWSKA AM, LUYTEN C, VINTS A-M, VERBRAECKEN J, Vanranst D, Debacker WA. Respirology 2006; 11: 741-747 Objective and background: 

Existence of an increased oxidative stress has been confirmed in patients with acute exacerbation of COPD. This study aims to examine the extent and time-course of antioxidant defence in patients with an acute exacerbation of COPD in comparison with stable patients. Methods: 

Twelve patients with acute exacerbation were studied at admission, and then 24 h and 48 h following admission and at discharge. The antioxidants assessed were the endogenous antioxidants: glutathione peroxidase, superoxide dismutase, oxidized and reduced glutathione, albumin and exogenous antioxidants: α-tocopherol and retinol. Trolox equivalent antioxidant capacity as a marker of antioxidant status was also measured. Results: 

There was an increase in glutathione peroxidase and superoxide dismutase 48 h after admission (P < 0.05). α-Tocopherol was the lowest 24 h after admission and increased significantly at discharge (P < 0.05). Conclusions: 

There is an increase in antioxidant defence during acute exacerbation of COPD reaching a maximum at 48 h after admission. This rise in the antioxidant defence is not sufficient to prevent depletion of non-enzymatic antioxidants such as α-tocopherol.", pages = "741-747(7)", url = "http://www.ingentaconnect.com/content/bsc/res/2006/00000011/00000006/art00012" doi = "doi:10.1111/j.1440-1843.2006.00943.x" }