@article {Mashiko:April 1999:1323-1316:193, author = "Mashiko, Hirobumi", author = "Niwa, Shin-Ichi", author = "Kumashiro, Hisashi", author = "Kaneko, Yoshihiro", author = "Suzuki, Satoru", author = "Numata, Yoshihiko", author = "Horikoshi, Ryu", author = "Watanabe, Yoshinori", title = "Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: Dose-finding study with no concomitant use of hypnotic agent", journal = "Psychiatry and Clinical Neurosciences", volume = "53", year = "April 1999", abstract = "This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.", pages = "193-194(2)", url = "http://www.ingentaconnect.com/content/bsc/pcn/1999/00000053/00000002/art00025" doi = "doi:10.1046/j.1440-1819.1999.00532.x" }