@article {De Roos:September 2000:0954-6820:211,
author = "De Roos, B.",
author = "Van Tol, A.",
author = "Urgert, R.",
author = "Scheek, L. M.",
author = "Van Gent, T.",
author = "Buytenhek, R.",
author = "Princen, H. M. G.",
author = "Katan, M. B.",
title = "Consumption of French-press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects",
journal = "Journal of Internal Medicine",
volume = "248",
year = "September 2000",
abstract = ". de Roos B, van Tol A, Urgert R, Scheek LM, van Gent T, Buytenhek R, Princen HMG, Katan MB (Wageningen University; Erasmus University, Rotterdam; and Gaubius Laboratory, Leiden; Wageningen Centre for Food Sciences, The Netherlands). Consumption of French-press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects. J Intern Med 2000; 248: 211-216. Objectives. To determine the long-term effects of unfiltered coffee consumption on the activity levels of cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) and to assess a possible role of CETP activity levels in the rise in serum LDL cholesterol. Subjects and design. Forty-six healthy normolipidaemic subjects consumed 0.9 L of either French-press or filtered coffee for 24 weeks. Fasting blood samples were obtained after 0, 2, 12 and 24 weeks of intervention and after and 12 weeks of follow-up. Main outcome measures. Serum activity levels of CETP, PLTP and LCAT. Results. Relative to baseline, French-press coffee significantly increased average CETP activity by 12% after 2 weeks, by 18% after 12 weeks, and by 9% after 24 weeks. PLTP activity was significantly increased by 10% after 12 and 24 weeks. LCAT activity was significantly decreased by 6% after 12 weeks and by 7% after 24 weeks. The increase in CETP clearly preceded the increase in LDL cholesterol, but not the increase in total triglycerides. However, consumption of French-press coffee caused a persistent rise in CETP activity, whereas the rise in serum triglycerides was transient. Conclusions. Consumption of cafestol and kahweol cause a long-term increase in CETP as well as PLTP activity; the increase in CETP activity may contribute to the rise in LDL cholesterol.",
pages = "211-216(6)",
url = "http://www.ingentaconnect.com/content/bsc/jint/2000/00000248/00000003/art00004"
doi = "doi:10.1046/j.1365-2796.2000.00728.x"
}