@article {Taxel:February 2004:0002-8614:269,
author = "Taxel, Pamela",
author = "Stevens, Michael C.",
author = "Trahiotis, Margaret",
author = "Zimmerman, Jill",
author = "Kaplan, Richard F.",
title = "The Effect of Short-Term Estradiol Therapy on Cognitive Function in Older Men Receiving Hormonal Suppression Therapy for Prostate Cancer",
journal = "Journal of the American Geriatrics Society",
volume = "52",
year = "February 2004",
abstract = "See editorial comments by Dr. Sanjay Asthana on pp 316-318. Objectives: To determine the effect of estrogen (E) alone (without the influence of testosterone (T)) on cognitive function in older men, using 17-β micronized estradiol versus placebo in older men rendered hypogonadal (low T and E) by treatment for prostate cancer. Design: Short-term double-blind, randomized, controlled trial. Setting: An outpatient General Clinical Research Center. Participants: Twenty-seven community-dwelling men aged 65 and older receiving neoadjuvant or established therapy with luteinizing-hormone releasing-hormone agonists for treatment of prostate cancer enrolled in a short-term randomized, controlled trial of 17-β micronized estradiol versus placebo on the effect on biochemical markers of bone turnover. Measurements: Hormone levels, including E, T, and sex hormone-binding globulin; standardized neurocognitive tests, including measures of sustained attention, executive function, and memory; and questionnaires to assess subjects' perception of cognitive deficits and symptoms of depression. Results: There were no significant differences between patients receiving E or placebo on 15 of 17 neurocognitive measures and no significant differences in self-reported cognitive deficits or number of depressive symptoms. Conclusion: Although studies have suggested that E replacement therapy may improve cognitive function, most notably memory performance in postmenopausal woman, there was no evidence in the present study that the addition of short-term E therapy was more beneficial than placebo in tests of cognitive performance in hypogonadal men.",
pages = "269-273(5)",
url = "http://www.ingentaconnect.com/content/bsc/jgs/2004/00000052/00000002/art00016"
doi = "doi:10.1111/j.1532-5415.2004.52067.x"
}