@article {Pillai:October 2005:0142-5463:292,
	author = "Pillai, R.",
	author = "Redmond, M.",
	author = "Roding, J.",
	title = "Anti-Wrinkle Therapy: Significant New Findings in the Non-Invasive Cosmetic Treatment of Skin Wrinkles with Beta-Glucan",
	journal = "International Journal of Cosmetic Science",
	volume = "27",
	year = "October 2005",
	abstract = "Oat beta-glucan is a water soluble, linear polymer of glucose consisting of 1,4 (70%) and 1,3 (30%) linkages with an average molecular weight of 1&#8201;&#215;&#8201;10<SUP>6</SUP>&#8201;Da. Scientific reports indicate beta-glucan is a film-forming moisturizer, a biological response modifier, and a promoter of wound healing. Our objective was to study the penetration of oat (1,4:1,3) beta-glucan in human skin models and to evaluate clinically its efficacy for reducing fine-lines and wrinkles. Penetration studies performed on human abdominal skin used a single application of 0.5% beta-glucan solution at a dose of 5&#8201;mg per cm<SUP>2</SUP>. The results showed that beta-glucan, despite its large molecular size, deeply penetrated the skin into the epidermis and dermis. A clinical study of 27 subjects was performed to evaluate the effects of beta-glucan on facial fine-lines and wrinkles. After 8&#8201;weeks of treatment, digital image analysis of silicone replicas indicated a significant reduction of wrinkle depth and height, and overall roughness. <P></P>This work is the first ex vivo and in vivo demonstration of the physiological effects of beta-glucan in the penetration and restructuring of human tissue. The study supports the use of oat beta-glucan in the care and maintenance of healthy skin and the cosmetic treatment of the signs of aging.",
	pages = "292-292(1)",
	url = "http://www.ingentaconnect.com/content/bsc/ics/2005/00000027/00000005/art00008"
	doi = "doi:10.1111/j.1463-1318.2005.00268_3.x"
}