@article {Silberstein:November/December 2001:0017-8748:953,
	author = "Silberstein S.D.",
	author = "McCrory D.C.",
	title = "Butalbital in the Treatment of Headache: History, Pharmacology, and Efficacy",
	journal = "Headache: The Journal of Head and Face Pain",
	volume = "41",
	year = "November/December 2001",
	abstract = "Analgesics containing butalbital compounded with aspirin, acetaminophen, and/or caffeine are widely used for the treatment of migraine and tension-type headache. The butalbital-containing compounds are efficacious in placebo-controlled trials among patients with episodic tension-type headaches. Despite their frequent clinical use for migraine, they have not been studied in placebo-controlled trials among patients with migraine. Barbiturates can produce intoxication, hangover, tolerance, dependence, and toxicity. Butalbital can result in intoxication that is clinically indistinguishable from that produced by alcohol. Butalbital-containing analgesics can produce drug-induced headache in addition to tolerance and dependence. Higher doses can produce withdrawal syndromes after discontinuation. Butalbital-containing analgesics may be effective as backup medications or when other medications are ineffective or cannot be used. Because of concerns about overuse, medication-overuse headache, and withdrawal, their use should be limited and carefully monitored.",
	pages = "953-967(15)",
	url = "http://www.ingentaconnect.com/content/bsc/hed/2001/00000041/00000010/art00010"
	doi = "doi:10.1046/j.1526-4610.2001.01189.x"
}