IngentaConnect A Randomized Pilot Study Comparing the Action Halos of Two Commer...

Authors: HEXSEL, DORIS¹; DAL'FORNO, TACIANA²; HEXSEL, CAMILE; PRADO, DÉBORA ZECHMEISTER DO; LIMA, MARYELLE MOREIRA

Source: Dermatologic Surgery, Volume 34, Number 1, January 2008 , pp. 52-59(8)

Abstract:

BACKGROUND

The determination of the action halos of botulinum toxin type A aids in targeting specific muscles and/or sweat glands, thereby preventing the occurrence of side effects. OBJECTIVES

The objective of this study was to compare the action halos of two commercial preparations of botulinum toxin type A, Dysport (Ipsen, Slough, UK) and BOTOX (Allergan, Irvine, CA). MATERIAL AND METHODS

Eighteen volunteers received applications of both products into randomized sides of the frontalis muscle. Equivalent doses of 5U of Dysport and 2U of BOTOX were injected using the same technique, in the same volume (0.02mL), and at a controlled depth. Twenty-eight days later, clinical and photographic assessments were performed. RESULTS

All the areas around the injected points were regular, round, or slightly oval and showed similar effects in the muscles and sweat glands. No statistically significant differences were observed between the mean sizes of the diameters of the halos produced by the two products. CONCLUSION

Injections of Dysport and BOTOX at an equivalence ratio of 2.5:1U, respectively, applied at the same volume and depth, using the same technique resulted in similar action halos with regard to muscular and sweat gland activity. Both products seem to be safe and very predictable.

The authors received partial sponsorship from Ipsen who donated the vials of Dysport and BOTOX used in this study.

Document Type: Research article

DOI: 10.1111/j.1524-4725.2007.34008.x

Affiliations: 1: School of Medicine, University of Passo Fundo, RS, Brazil; 2: Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;

A Randomized Pilot Study Comparing the Action Halos of Two Commercial Preparations of Botulinum Toxin Type A