IngentaConnect Complications of Systemic Retinoid Therapy in Organ Transplant Re...

Authors: Martinez, Juan-Carlos¹; Otley, Clark C.²; Euvrard, Sylvie³; Arpey, Christopher J.⁴; Stasko, Thomas⁵

Source: Dermatologic Surgery, Volume 30, Supplement 1, April 2004 , pp. 662-666(5)

Abstract:

Background.

Organ transplant recipients receiving immunosuppressive medications are at increased risk of cutaneous malignancies. Objective.

We sought to determine the complications associated with systemic retinoid therapy in severely affected organ transplant recipients receiving treatment before or during the course of metastatic squamous cell carcinoma. Methods.

This was a collaborative retrospective study of solid organ transplant recipients treated with systemic retinoids for severe squamous cell carcinoma, with subjective analysis of complications associated with treatment. Results.

Complications and intolerance of systemic retinoid therapy were common, necessitating discontinuation of therapy in six of eight cases. Conclusion.

This subset of transplant patients, severely affected by skin cancer, appeared to be less able to tolerate systemic retinoid therapy than patients in formal clinical trials. Intolerance of adverse effects in this context suggests the need for novel approaches with these challenging patients.

JUAN-CARLOS MARTINEZ, CLARK C. OTLEY, MD, SYLVIE EUVRARD, MD, CHRISTOPHER J. ARPEY, MD, AND THOMAS STASKO, MD HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.

Document Type: Research article

DOI: 10.1111/j.1524-4725.2004.30153.x

Affiliations: 1: Mayo Clinic College of Medicine and 2: Mayo Clinic, Rochester, Minnesota; 3: Hôpital Edouard Herriot, Lyon, France; 4: University of Iowa College of Medicine, Iowa City, Iowa; and 5: Vanderbilt University School of Medicine, Nashville, Tennessee

Complications of Systemic Retinoid Therapy in Organ Transplant Recipients With Squamous Cell Carcinoma