Acute Excisional Wounds Treated with a Tissue-Engineered Skin (Apligraf)

Authors: Eaglstein W.H.1, *; Alvarez O.M.2; Auletta M.3; Leffel D.4; Rogers G.S.5; Zitelli J.A.6; Norris J.E.C.7; Thomas I.7; Irondo M.8; Fewkes J.9; Hardin-Young J.10; Duff R.G.10; Sabolinski M.L.10

Source: Dermatologic Surgery, Volume 25, Number 3, March 1999 , pp. 195-201(7)

Publisher: Blackwell Publishing

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Abstract:

background.

Tissue-engineered products are usually composed of living cells and their supporting matrices that have been grown in vitro, using a combination of engineering and life sciences principles. Apligraf is a bilayered product composed of neonatal-derived dermal fibroblasts and keratinocytes, and Type I bovine collagen.

objective.

To evaluate in a prospective, multicentered open study, the effects of tissue therapy with a tissue-engineered skin (Apligraf) with partial or full-thickness excisional wounds.

methods.

One hundred and seven patients participated in this study. The tissue-engineered skin was applied once, immediately after excisional surgery, usually for skin cancer, and patients were followed for up to one year.

results.

The safety results were impressive, with no clinical or laboratory evidence of rejection. Clinically, graft persistence was good to excellent in 77 of 105 (73.3%) of patients at one week, falling to 56.6% and 53.6% at two weeks and one month respectively.

conclusion.

To date, this is the largest experience with a tissue-engineered skin product in acute wounds, and this study suggests that tissue therapy may be safe and useful.

Language: English

Document Type: Research article

Affiliations: 1: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida 10: Organogenesis, Inc., Canton, Massachusetts 2: University Wound Healing Clinic, New Brunswick, New Jersey 3: Robert Wood Johnson Medical School Division of Dermatology, New Brunswick, New Jersey 4: Department of Dermatology, Yale School of Medicine, New Haven, Connecticut 5: Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 6: University of Pittsburgh Medical Center—Shadyside, Pittsburgh, Pennsylvania 7: New York, New York 8: Miami, Florida 9: Massachusetts General Hospital, Boston, Massachusetts *

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