Circadian variation of the cell proliferation in the jejunal epithelium of rats at weaning phase

Authors: Gomes, J. R.; Pereira, A. A. M.1; Barth, L.1; Silva, J. S.1; Leite, M. L.1; Wille, A. C. M.1; Soares, M. A. M.1

Source: Cell Proliferation, Volume 38, Number 3, June 2005 , pp. 147-152(6)

Publisher: Blackwell Publishing

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Abstract:

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 Circadian variation in cell proliferation of the jejunal epithelium of 18-day-old rats was studied using the 2-h arrested metaphase score and crypt isolation method. A continuous decrease in the arrested metaphases occurred from 07.00 h to13.00 h. From 17.00 h arrested metaphase values increased and were maintained at the higher level during the dark period as showed by Cosinor analyses (P < 0.05). These results indicate that in the young rat there is already a circadian variation in jejunal epithelial cell proliferation as early as 18 days. We can even suggest that the presence of a circadian rhythm at weaning contributes to the steady state of cell proliferation in the intestinal epithelium observed in adult life.

Document Type: Research article

DOI: 10.1111/j.1365-2184.2005.00339.x

Affiliations: 1: Departamento de Biologia Estrutural, Molecular e Genética. Setor de Ciências Biológicas e da Saúde, Universidade Estadual de Ponta Grossa, Paraná, Brazil

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