IngentaConnect Immunohistochemical analysis of paragangliomas

Authors: Mey¹; Corver¹; Jansen¹; Cornelisse¹

Source: Clinical Otolaryngology & Allied Sciences, Volume 23, Number 2, April 1998 , pp. 188-188(1)

Abstract:

Objective. To find a biological marker that can give information about the clinical behaviour of head and neck paragangliomas.

Materials and methods. Immunohistochemical analysis was performed on 114 paragangliomas of which 68 were hereditary. A broad panel comprising eight chief cell (type 1) markers (PGP 9.5, NSE, Leu-Enkephalin, Met-Enkephalin, Chromogranin, Serotonin, Somatostatin, HNK-Leu 7) and two sustentacular cell (type 2) markers (S 100, GFAP) were applied to paraffin embedded slides.

Results. It was possible to distinguish between chief andsustentacular cells on the basis of marker specificity but no significant correlation between staining pattern and clinical criteria indicative of tumour progression, DNA-ploidy or tumour localization was found.

Conclusion. Clinically immunohistochemical reactivity ofparagangliomas cannot serve as a marker for their growth pattern, furthermore one could hypothesize for the used panel of markers that the underlying cause of their clinically different behaviour is not reflected by diminished differentiation as might be reflected by decreased production of tumour associated antigens or hormones.

Keywords: audiometry; otosclerosis; second ear; stapedectomy

Document Type: Abstract

DOI: 10.1046/j.1365-2273.1998.0119h.x

Affiliations: 1: Leiden, The Netherlands

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