IngentaConnect Can pretreatment CT findings predict local control in T3 glottic ...

Authors: Pameijer¹; Mancuso¹; Mendenhall¹; Parsons¹; Kubilis¹

Source: Clinical Otolaryngology & Allied Sciences, Volume 23, Number 2, April 1998 , pp. 186-186(1)

Abstract:

Objective. To determine if pretreatment computed tomography (CT) findings can predict local control in T3 glottic carcinoma treated with definitive radiotherapy (RT).

Patients and methods. Forty-two patients with a previously untreated T3 laryngeal carcinoma were treated for cure with RT, all had a minimum 2-year follow-up. Tumour volume and extent were determined on pre-treatment CT studies. The specific parameters were correlated with local control.

Results. There was a significant decrease in local control rate for tumours over 3.5 cc (25%) versus tumours under 3.5 cc (85%; P = 0.0002). Tumour score, as a measure of anatomical extent, also correlated with local control (P = 0.002). Patients with isolated cartilage sclerosis showed no decrease in local control rate whereas in patients with sclerosis of more than one laryngeal cartilage the local control rate decreased to 33.3% (P = 0.021).

Conclusion. CT can stratify T3 glottic carcinoma into groups more or less likely to be locally controlled with definitive RT. Local control rates can be improved by using a CT-based tumour profile. The ideal CT profile for a radiocurable T3 glottic carcinoma is: volume <3.5 cc; tumour score ≤5, and no or single cartilage sclerosis.

Keywords: audiometry; otosclerosis; second ear; stapedectomy

Document Type: Abstract

DOI: 10.1046/j.1365-2273.1998.0119c.x

Affiliations: 1: Gainesville, Florida, USA/Amsterdam, The Netherlands

Can pretreatment CT findings predict local control in T3 glottic carcinoma treated with radiotherapy alone?