IngentaConnect Treatment outcome in young patients with squamous cell carcinoma ...

Authors: Verschuur¹; Irish¹; O'sullivan¹; Pintilie¹; Goh¹; Gullane¹

Source: Clinical Otolaryngology & Allied Sciences, Volume 23, Number 2, April 1998 , pp. 186-186(1)

Abstract:

Objective. Determination of the treatment outcome in young patients with squamous cell carcinoma of the upper aerodigestive tract (UADT-SCC).

Patients and methods. One hundred and eighty-five previously untreated UADT-SCC patients younger than 40 years seen at the Princess Margaret Hospital, Toronto between 1958 and 1992 were analysed. The results were compared to a control group of older patients (>40 years), matched according to site, sex and date of presentation. A multivariate regression analysis was performed. Patients with metastatic disease at presentation, previous or concurrent malignancies, nasopharyngeal carcinoma, verrucous carcinoma, carcinoma in situ and unknown primaries were excluded.

Results. The 5-year cause-specific survival in both groups was the same (72% versus 68% P = 0.91). Tumour stage and treatment modalities were comparable in both groups. Older patients developed significantly more subsequent primaries than the younger patients (n = 34 versusn = 15, P = 0.005). There were significantly fewer smokers and drinkers in the younger patient group. Smoking had an important impact on outcome. All but one patient who developed second primaries in the head and neck, lung or oesophagus were smokers.

Conclusion. Our data show that the dogma that younger patients with UADT-SCC have a worse prognosis cannot be proven in this large case-controlled study.

Keywords: audiometry; otosclerosis; second ear; stapedectomy

Document Type: Abstract

DOI: 10.1046/j.1365-2273.1998.0119b.x

Affiliations: 1: Den Haag, Toronto, Canada

Treatment outcome in young patients with squamous cell carcinoma of the upper aerodigestive tract: a matched control study