IngentaConnect Ringing the alarm bells: signalling and apoptosis in influenza vi...

Authors: Ludwig, Stephan; Pleschka, Stephan¹; Planz, Oliver²; Wolff, Thorsten³

Source: Cellular Microbiology, Volume 8, Number 3, March 2006 , pp. 375-386(12)

Publisher: Blackwell Publishing

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Abstract:

Summary

Small RNA viruses such as influenza viruses extensively manipulate host-cell functions to support their replication. At the same time the infected cell induces an array of defence mechanisms to fight the invader. These processes are mediated by a variety of intracellular signalling cascades. Here we will review the current knowledge of functional kinase signalling and apoptotic events in influenza virus infected cells and how these viruses have learned to misuse these cellular responses for efficient replication.

Document Type: Research article

DOI: 10.1111/j.1462-5822.2005.00678.x

Affiliations: 1: Institute of Medical Virology, Justus-Liebig-University, Frankfurter Str. 107, D-35392 Giessen, Germany. 2: Institute of Immunology, Friedrich-Loeffler-Institute (FLI), Paul-Ehrlich Str. 28, D-72076 Tübingen, Germany. 3: Robert-Koch Institute (RKI), Nordufer 20, 13353 D-Berlin, Germany.

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Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells