Immunity to vacuolar pathogens: What can we learn from Legionella?
Authors: Annie L. Neild1; Craig R. Roy
Source: Cellular Microbiology, Volume 6, Number 11, November 2004 , pp. 1011-1018(8)
Publisher: Blackwell Publishing
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Abstract:
Summary Intracellular pathogens can manipulate host cellular pathways to create specialized organelles. These pathogen-modified vacuoles permit the survival and replication of bacterial and protozoan microorganisms inside of the host cell. By establishing an atypical organelle, intracellular pathogens present unique challenges to the host immune system. To understand pathogenesis, it is important to not only investigate how these organisms create unique subcellular compartments, but to also determine how mammalian immune systems have evolved to detect and respond to pathogens sequestered in specialized vacuoles. Recent studies have identified genes in the respiratory pathogen Legionella pneumophila that are essential for establishing a unique endoplasmic reticulum-derived organelle inside of mammalian macrophages, making this pathogen an attractive model system for investigations on host immune responses that are specific for bacteria that establish vacuoles disconnected from the endocytic pathway. This review will focus on the host immune response to Legionella and highlight areas of Legionella research that should help elucidate host strategies to combat infections by intracellular pathogens.Document Type: Research article
DOI: 10.1111/j.1462-5822.2004.00450.x
Affiliations: 1: Yale University School of Medicine, Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 USA
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