Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV
Authors: Vojo Deretic; Isabelle Vergne1; Jennifer Chua1; Sharon Master1; Sudha B. Singh1; Joseph A. Fazio1; George Kyei1
Source: Cellular Microbiology, Volume 6, Number 11, November 2004 , pp. 999-1009(11)
Publisher: Blackwell Publishing
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Abstract:
Summary Inhibition of phagolysosome biogenesis in infected macrophages is a classical pathogenesis determinant of Mycobacterium tuberculosis. In this review we primarily cover the cellular mechanisms of M. tuberculosis phagosome maturation arrest. A detailed picture is beginning to emerge, involving regulators of membrane trafficking in mammalian cells and phagosomal interactions with endosomal organelles and the trans-Golgi network. We also present a hypothesis that overlaps may exist between the mycobacterial interference with the host cell membrane trafficking processes and the targeting of the late endosomal sorting machinery by HIV during viral budding in macrophages. We propose that interference with the endosomal sorting machinery contributes to the synergism between the two significant human diseases – AIDS and tuberculosis.Document Type: Research article
DOI: 10.1111/j.1462-5822.2004.00449.x
Affiliations: 1: Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131–001, USA
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