Nonmyeloablative peripheral blood stem cell transplant for T-cell prolymphocytic leukaemia complicated by fulminant haemolysis and acute renal failure at engraftment secondary to minor ABO incompatibility

Authors: CURTIN, N. J.¹; SCHWARER, A. P.²

Source: Clinical & Laboratory Haematology, Volume 27, Number 3, June 2005 , pp. 206-208(3)

Abstract:

Summary

We present a 54-year-old man who underwent human leucocyte antigen-identical sibling nonmyeloablative peripheral blood stem cell transplant for primary refractory T-cell prolymphocytic leukaemia (T-PLL). His clinical course was complicated by fulminant haemolysis and acute renal failure at the time of engraftment because of minor ABO incompatibility between the donor and the recipient. This case highlights the curative potential of nonmyeloablative transplantation for T-PLL as well as the potential severity of immune haemolysis secondary to minor ABO incompatibility.

Keywords: T-cell prolymphocytic leukaemia; nonmyeloablative peripheral blood stem cell transp; immune haemolysis

Document Type: Research article

DOI: 10.1111/j.1365-2257.2005.00690.x

Affiliations: 1: Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK 2: Clinical Haematology and Bone Marrow Transplant Unit, The Alfred Hospital, Melbourne, VIC, Australia

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