Molecular genetic analysis of haematological malignancies: I. Acute leukaemias and myeloproliferative disorders

Authors: BENCH, A. J.; ERBER, W. N.; SCOTT, M. A.

Source: Clinical & Laboratory Haematology, Volume 27, Number 3, June 2005 , pp. 148-171(24)

Publisher: Blackwell Publishing

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Abstract:

Summary

Molecular genetic techniques are now routinely applied to haematological malignancies within a clinical laboratory setting. The detection of genetic rearrangements not only assists with diagnosis and treatment decisions, but also adds important prognostic information. In addition, genetic rearrangements associated with leukaemia can be used as molecular markers allowing the detection of low levels of residual disease. This review will concentrate on the application of molecular genetic techniques to the acute leukaemias and myeloprolferative disorders.

Keywords: Molecular analysis; acute leukaemia; chronic myeloproliferative disorders; minimal residual disease; polymerase chain reaction

Document Type: Research article

DOI: 10.1111/j.1365-2257.2005.00701.x

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