Inherited protein C deficiency, protein S deficiency and hyperhomocysteineaemia in a patient with hereditary spherocytosis

Authors: Taylor, C. P. F.¹; Luckit, J. K.²; Perry, D. J.¹

Source: Clinical & Laboratory Haematology, Volume 21, Number 3, June 1999 , pp. 211-214(4)

Publisher: Blackwell Publishing

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Abstract:

We report a family with hereditary spherocytosis in whom there is, in addition, a cluster of genetic predispositions to thrombosis. Although inherited prothrombotic abnormalities are prevalent in the general population, the likelihood of this combination of abnormalities being found in a single family is extremely low. The management of such high risk individuals is discussed.

Keywords: Hereditary spherocytosis; homocysteine; protein C; protein S; thrombosis

Document Type: Research article

DOI: 10.1046/j.1365-2257.1999.00209.x

Affiliations: 1: Haemophilia Centre & Haemostasis Unit, Department of Haematology, Royal Free & University College School of Medicine at UCL, London and 2: Department of Haematology, North Middlesex Hospital, London

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