Multiple chromosomal abnormalities in fulminant anaplastic myeloma
Authors: Maslovsky, I.1; Lugassy, G.1; Blumental, R.1; Ducach, A.1; Yehuda, O.2; Abeliovich, D.2
Source: Clinical & Laboratory Haematology, Volume 21, Number 3, June 1999 , pp. 207-210(4)
Publisher: Blackwell Publishing
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Abstract:
We describe a 58-year-old woman with anaplastic multiple myeloma and multiple chromosomal abnormalities. Her karyotype showed extreme hyperploidy with 77 chromosomes. Some of the aberrations were typical of multiple myeloma (+3, +5, +15, +19, +21, t(11; 14)(q13; q32)), others were characteristic of the aggressive anaplastic myeloma (+8), t(11; 14)(q13; q32), while three chromosomal abnormalities (t(11; 20)(p11; q13); t(4; 7)(q31; q11); and t(14; 20)(q24; q13)) have not been, to the best of our knowledge, described previously in the literature. The fulminant course of the disease confirms the poor prognosis of multiple karyotypic abnormalities in myeloma.Keywords: Anaplastic; karyotypic aberrations; multiple myeloma
Document Type: Research article
DOI: 10.1046/j.1365-2257.1999.00207.x
Affiliations: 1: Hematology Institute, Barzilai Medical Center, Ashkelon, affiliated to the Faculty of Health Sciences Ben-Gurion University of the Negev, Israel, and, 2: Institute of Cytogenetics, Hadassah University Hospital, Jerusalem, Israel
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