IngentaConnect Impaired T-lymphocyte function in B-chronic lymphocytic leukaemia...

Authors: Stark, P.¹; Shohat, B.¹; Kadosh, S.¹; Shaklai, M.¹

Source: Clinical & Laboratory Haematology, Volume 21, Number 3, June 1999 , pp. 187-192(6)

Abstract:

The immunological dysfunction observed in B-chronic lymphocytic leukaemia (B-CLL) is often related to T-lymphocyte incompetence. The local xenogeneic graft-vs.-host reaction (XGVHR), an assay to evaluate T-lymphocyte function, was performed in 112 untreated B-CLL patients. The XGVHR results significantly correlated with clinical parameters: 37.1% of the patients in the stable phase (Rai stage 0-1-2) and only 13.3% of the patients in the progressive phase (Rai stage 3-4) had positive XGVHR results. Patients with negative results had a higher number and percentage of lymphocytes (25 247 vs. 17 071/μl and 75.9% vs. 65.6%, respectively), much lower T/B lymphocyte ratio (0.37 vs. 0.93), higher WBC count (30 977 vs. 23 458/μl), lower platelet count (158 068 vs. 181 684/μl) and lower levels of IgA and IgM (115.6 vs. 200.5 mg/dl and 80.4 vs. 124.3 mg/dl, respectively) compared to those with positive results. Among those with negative XGVHR results, a higher mortality rate was found in those who had infections compared with those who did not (73.7% vs. 9.1%). In conclusion, the XGVHR assay significantly correlates with important characteristics of B-CLL and may be useful in the clinical evaluation of B-CLL patients.

Keywords: B-lymphocyte; chronic lymphocytic leukaemia; immune system; local xenogeneic graft-vs.-host reaction; T-lymphocyte

Document Type: Research article

DOI: 10.1046/j.1365-2257.1999.00211.x

Affiliations: 1: Institute of Hematology, Rabin Medical Center, Beilinson Campus, Petah-Tiqva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Impaired T-lymphocyte function in B-chronic lymphocytic leukaemia as measured by the local xenogeneic graft-versus-host reaction