Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF

Authors: RANAGHAN¹; DRAKE¹; HUMPHREYS²; MORRIS¹

Source: Clinical & Laboratory Haematology, Volume 20, Number 1, February 1998 , pp. 49-51(3)

Publisher: Blackwell Publishing

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Abstract:

We describe a patient with M4 AML treated with standard chemotherapy followed by G-CSF who developed marked monocytosis on day 8 of G-CSF therapy. Fourteen days after discontinuation of G-CSF therapy his monocyte counts returned to normal levels and a marrow aspirate showed a reduction in blast cells. He received further chemotherapy without G-CSF and without any recurrence of the raised leucocyte count but failed to achieve full remission. Although this G-CSF-driven leucocytosis was alarming it did not appear to have adversely affected the patient's prognosis.

Keywords: Myeloid leukaemia; G-CSF; monocytosis

Document Type: Research article

DOI: 10.1046/j.1365-2257.1998.00083.x

Affiliations: 1: Department of Haematology, Belfast City Hospital, UK, 2: Department of Cytogenetics, Belfast City Hospital, UK

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