IngentaConnect Evaluation of reproductive and developmental toxicity of the rubb...

Authors: Ema, Makoto; Fujii, Sakiko¹; Yabe, Kaoru¹; Matsumoto, Mariko²; Hirata-Koizumi, Mutsuko²

Source: Congenital Anomalies, Volume 47, Number 4, December 2007 , pp. 149-155(7)

Abstract:

Male and female Crl:CD(SD) rats were fed a diet containing the rubber accelerator N,N-dicyclohexyl-2-benzothiazolesulfenamide (DCBS) at 0, 1500, 3000, 6000 or 10 000 p.p.m. (0, 83, 172, 343 or 551 mg/kg bw/day in males and 0, 126, 264, 476 or 707 mg/kg bw/day in females) for a total of 57 days beginning 16 days before mating in males, and a total of 61-65 days from 16 days before mating to day 21 of lactation in females. Body weight gains and food consumption were reduced in males at 6000 p.p.m. and higher and in females at 3000 p.p.m. and higher. The weights of the spleen at 6000 and 10 000 p.p.m. and of the thymus at 10 000 p.p.m. were decreased in females. No changes in estrous cyclicity, copulation index, fertility index, gestation index, delivery index, precoital interval or gestation length were observed at any dose of DCBS. Numbers of implantations at 6000 and 10 000 p.p.m. and pups delivered at 10 000 p.p.m. were reduced. There were no changes in the sex ratio or viability of pups. The body weights of male and female pups were lowered at 6000 p.p.m. and higher. Decreased weight of the spleen in weanlings was also observed in males at 1500 p.p.m. and higher and in females at 3000 p.p.m. and higher. The data indicate that DCBS possesses adverse effects on reproduction and development in rats.

Keywords: developmental toxicity; N; N-dicyclohexyl-2-benzothiazolesulfenamide; rat; reproductive toxicity; rubber accelerator

Document Type: Research article

DOI: 10.1111/j.1741-4520.2007.00161.x

Affiliations: 1: Safety Research Institute for Chemical Compounds, Sapporo, Japan 2: Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, and

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.39 plus tax Refund Policy

Evaluation of reproductive and developmental toxicity of the rubber accelerator N,N-dicyclohexyl-2-benzothiazolesulfenamide in rats