PROTEOMICS TECHNOLOGY AND THERAPEUTICS

Authors: Hong, Michelle Li Wen; Jiang, Nan; Gopinath, Sravanthy; Chew, Fook Tim

Source: Clinical and Experimental Pharmacology and Physiology, Volume 33, Numbers 5-6, May/June 2006 , pp. 563-568(6)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

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Proteins are the workhorses of biological systems and, thus, it is not surprising that the field of proteomics has flourished in recent years. The present review briefly surveys the general proteomic approaches taken to identify drug targets and to evaluate drug efficacy and toxicity in the preclinical and clinical settings. These generally fall into three basic categories: a profiling approach, a functional approach and a structural approach.

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The current `tools' used and applied to the drug-discovery process will be highlighted. These include the two-dimensional gel electrophoresis, liquid chromatography, mass spectrometry, isotope-coded affinity tag and protein biochips.

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Clearly, proteomics has begun to set a foothold in every stage of the drug-discovery process. Future developments in this area will likely make a significant impact in our quest for better, safer and cost-effective drugs.

Keywords: chromatographic techniques; drug-discovery process; mass spectrometry; protein chips; proteomics technologies; two-dimensional gel electrophoresis

Document Type: Research article

DOI: 10.1111/j.1440-1681.2006.04407.x

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