POLYMERIC CORE-SHELL NANOPARTICLES FOR THERAPEUTICS

Authors: Yang, Yi-Yan; Wang, Yong; Powell, Ross; Chan, Peggy

Source: Clinical and Experimental Pharmacology and Physiology, Volume 33, Numbers 5-6, May/June 2006 , pp. 557-562(6)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

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Nanobiotechnologies have recently attracted significant attention from chemists, biologists, engineers and pharmaceutical scientists. In particular, they have been widely applied to improve drug, protein/peptide and gene delivery.

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This review presents recent advances in the field of drug, protein/peptide and gene delivery using natural and synthetic polymer nanoparticles and explains how polymeric nanoparticles are specifically designed to suit the needs for targeted delivery of small molecular drugs, proteins/peptides and genes. In addition, some of the challenges and prospects for these technologies are discussed.

Keywords: cationic polymer nanoparticles; drug delivery; gene delivery; peptide/protein delivery; polymer core-shell nanoparticles; polymeric nanoparticles

Document Type: Research article

DOI: 10.1111/j.1440-1681.2006.04408.x

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