DNA VACCINES AND ALLERGIC DISEASES

Authors: Chua, Kaw Yan; Huangfu, Taoqi; Liew, Lip Nyin

Source: Clinical and Experimental Pharmacology and Physiology, Volume 33, Numbers 5-6, May/June 2006 , pp. 546-550(5)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

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Allergic diseases are characterized by inappropriate immune responses to common environmental antigens. The prevalence of these diseases has been increasing worldwide for reasons that are not exactly clear.

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Current treatment is largely symptomatic. Because the initial observation that simple plasmid DNA injections resulted in in vivo protein expression and induction of adaptive immune responses to the encoded antigen, the potential of modifying the allergic immune responses by DNA vaccination so as to treat and prevent these diseases has been explored extensively.

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In the present paper we review preclinical studies using animal models of allergic diseases, with an emphasis on DNA vaccine design, for house dust mite allergens-related allergic asthma.

Keywords: allergen gene vaccination; allergy; asthma; DNA vaccines; house dust mites; vaccine optimization

Document Type: Research article

DOI: 10.1111/j.1440-1681.2006.04405.x

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