IngentaConnect THERAPEUTIC VACCINATION FOR CENTRAL NERVOUS SYSTEM REPAIR

Authors: Ang, Beng Ti; Xu, Gang; Xiao, Zhi Cheng

Source: Clinical and Experimental Pharmacology and Physiology, Volume 33, Numbers 5-6, May/June 2006 , pp. 541-545(5)

Publisher: Blackwell Publishing

Abstract:

SUMMARY

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Vaccination against infectious agents has been heralded as a triumph in modern medicine and, more recently, cancer vaccines have risen in prominence. The present review looks towards the use of vaccine therapy to attenuate damage after injury to the central nervous system (CNS).

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Significant debility is associated with brain injury, most commonly occurring as a result of physical trauma or stroke. This end result reflects the inability of neurons and axons to regenerate following injury to the CNS. This unconducive environment is due, in large part, to the presence of myelin and oligodendrocyte-related inhibitors of neurite outgrowth.

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We review how a vaccine-based approach has been variably used to circumvent this issue and promote axonal regeneration and repair following traumatic injury and other neurodegenerative disorders. In addition, emerging evidence suggests that the immune response to injury in the CNS may be manipulated so as to reduce cellular damage. Vaccine-directed approaches using this concept are also outlined.

Keywords: axonal regeneration; myelin-associated glycoprotein; neurodegeneration; Nogo; tenascin; vaccine

Document Type: Research article

DOI: 10.1111/j.1440-1681.2006.04404.x

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