CD4+CD25+ REGULATORY T CELLS IN HEALTH AND DISEASE
Authors: Liu, Haiying; Leung, Bernard P
Source: Clinical and Experimental Pharmacology and Physiology, Volume 33, Numbers 5-6, May/June 2006 , pp. 519-524(6)
Publisher: Blackwell Publishing
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Abstract:
SUMMARY • Over the past 5 years, tremendous progress has been made in understanding the suppressive mechanisms of T regulatory (Treg) cells. The Treg cells, a subpopulation of T cells, have been shown to play an important role in maintaining peripheral tolerance and the prevention of autoimmunity. • Various populations of Treg cells have been described, including thymically derived CD4+CD25+ Treg cells. These naturally occurring Treg cells are present in the periphery and are capable of suppressing proliferation and effector T cell responses both in vitro and in vivo. • In addition, a second subset of Treg cells, type 1 T regulatoary (Tr1) and Th3 cells, exert their suppressive capacity via cytokines such as interleukin-10 and transforming growth factor-b and are contact independent. • The present review summarizes the characteristics and molecular basis of CD4+CD25+ Treg cells, as well as their therapeutic potential in modulating inflammatory diseases, such as inflammatory bowel disease and rheumatoid arthritis.Keywords: cytokines; diseases; regulatory T cells
Document Type: Research article
DOI: 10.1111/j.1440-1681.2006.04401.x
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