CYTIDINE 5′-DIPHOSPHOCHOLINE RESTORES BLOOD FLOW OF SUPERIOR MESENTERIC AND RENAL ARTERIES AND PROLONGS SURVIVAL TIME IN HAEMORRHAGED ANAESTHETIZED RATS
Authors: Yilmaz, M Sertac; Yalcin, Murat; Savci, Vahide
Source: Clinical and Experimental Pharmacology and Physiology, Volume 33, Numbers 5-6, May/June 2006 , pp. 415-420(6)
Publisher: Blackwell Publishing
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Abstract:
SUMMARY • The aim of the present study was to investigate the effect of the intracerebroventricular (i.c.v.) or intravenous (i.v.) administration of cytidine 5¢-diphosphocholine (CDP-choline) on superior mesenteric artery (SMA) and renal artery (RA) blood flow, along with the cardiovascular parameters and survival time of anaesthetized rats under conditions of haemorrhagic shock. • Rats were anaesthetized with urethane (1.25 g/kg, i.p.) and acute haemorrhage was mimicked by the withdrawal of a total volume of 2–2.1 mL blood/100 g bodyweight over a period of 20 min. The CDP-choline was injected i.c.v. (1.0, 1.5 and 2.0 mmol) or i.v. (250 mg/kg) after the end of haemorrhage. Blood pressure, heart rate, SMA and RA flow values and the survival time of rats were recorded. Changes in blood flow were estimated by laser-Doppler flowmetry. • The haemorrhage procedure decreased the blood pressures of rats by 60% and limited their survival time to 22 ± 2 min. Both SMA and RA flow decreased to approximately 25% of initial values at the end of the haemorrhage procedure. • The i.c.v. administration of CDP-choline (1.0, 1.5 and 2.0 mmol) increased blood pressure and partially reversed the hypotension in a dose- and time-dependent manner. At 1.5 and 2.0 mmol, i.c.v., CDP-choline completely restored the decreased flow of the RA and transiently reversed hypoperfusion of the SMA. It also produced an almost fourfold increase in the survival time of rats. • The i.v. administration of CDP-choline (250 mg/kg) also completely, but transiently, restored SMA and RA flow, whereas it increased blood pressure by only 40% compared with control values. The survival time of rats in the i.v. CDP-choline group was doubled that of control. • These results indicate that both centrally and peripherally injected CDP-choline can restore SMA and RA flow, together with a partial reversal of hypotension and an increase in the survival time of rats.Keywords: blood flow; cytidine 5′-diphosphocholine; hypotension; renal artery; shock; superior mesenteric artery; survival
Document Type: Research article
DOI: 10.1111/j.1440-1681.2006.04382.x
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