IngentaConnect CIRCULATING SURFACTANT PROTEIN-B LEVELS INCREASE ACUTELY IN RESPO...

Abstract:

SUMMARY

1. As a result of its enormous surface area and necessary thinness for gas exchange, the alveolocapillary barrier is vulnerable to mechanical disruption from raised pulmonary microvascular pressure (P_mv).

2. Because surfactant protein-B (SP-B) leaks into the blood stream from the alveoli in response to alveolocapillary barrier damage and exercise leads to increased P_mv, we sought to determine whether exercise results in increased plasma SP-B. Moreover, in the setting of exercise-induced left ventricular dysfunction, the consequent increase in left heart filling pressure and, therefore, P_mv would be expected to further increase plasma SP-B levels.

3. Twenty consecutive subjects referred for treadmill exercise stress echocardiography (ESE) had venous blood sampled immediately before and after ESE for batch atrial natriuretic peptide (ANP) and SP-B assay. Echocardiographic measures of pulmonary haemodynamics (pulmonary artery flow acceleration time (pafAT) and right ventricular outflow tract velocity time integral (rVTI)) were also taken pre- and post-exercise.

4. Although circulating ANP levels increased following exercise (P < 0.001), there was no change in circulating SP-B levels in the entire cohort.

5. Ten subjects had a positive ESE for ventricular dysfunction. Although circulating ANP was increased post-exercise in both the negative and positive ESE groups (P < 0.05 and P < 0.01, respectively), circulating SP-B only increased post-exercise in the positive ESE group (P < 0.05). Echocardiographic parameters supported an increment in P_mv in the cohort with exercise-induced left ventricular dysfunction because this group had an increase in pafAT (P < 0.05; reflecting pulmonary artery pressure) and no change in rVTI.

6. Physical exertion associated with a Bruce protocol ESE is insufficient to increase circulating SP-B, despite evidence of increased left atrial and pulmonary vascular pressure. However, in the setting of exercise-induced myocardial dysfunction, there is a detectable increase in circulating SP-B.

7. The exaggerated increase in pulmonary vascular pressure in exercise-induced myocardial dysfunction may result in increased SP-B leakage from the alveoli into the circulation by altering the integrity of the alveolocapillary barrier to protein.

Keywords: atrial natiuretic peptide; capillary fragility; capillary permeability; echocardiography; exercise test; pulmonary circulation; surfactant protein-B; ventricular pressure

Document Type: Original article

DOI: 10.1111/j.0305-1870.2005.04241.x

Affiliations: 1: Cardiac Services, 2: Cardiology Department, Royal Perth Hospital and West Australian Institute of Medical Research, Perth, Western Australia, Australia 3: Physiology Department, Flinders University of South Australia, Adelaide, South Australia and 4: Veterans Heart Clinic, Repatriation General Hospital and 5: Critical Care Unit, Flinders Medical Centre,

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CIRCULATING SURFACTANT PROTEIN-B LEVELS INCREASE ACUTELY IN RESPONSE TO EXERCISE-INDUCED LEFT VENTRICULAR DYSFUNCTION