Role Of Excitatory Amino Acid Inputs To The Rostral Ventrolateral Medulla In Cardiovascular Regulation
Authors: Sved, Alan F1; Ito, Satoru2; Yajima, Yoshiharu1
Source: Clinical and Experimental Pharmacology and Physiology, Volume 29, Numbers 5-6, May/June 2002 , pp. 503-506(4)
Publisher: Blackwell Publishing
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Abstract:
SUMMARY 1. Excitatory amino acid (EAA)-mediated neural transmission in the rostral ventrolateral medulla (RVLM) is important for many cardiovascular reflexes, although the receptor subtypes involved vary depending on the specific response.2. Although injection of the EAA ionotropic receptor antagonist kynurenic acid into the RVLM has no effect on baseline arterial pressure, this lack of effect appears to result from EAA inputs to RVLM exciting both excitatory and inhibitory mechanisms within the RVLM.3. The balance between EAA-mediated excitation and inhibition of RVLM neurons may be shifted to excitation in experimental models of hypertension.4. The excitatory influence that EAA inputs to the RVLM have on vasomotor neurons in the RVLM may involve a sarthran-sensitive intermediary in the RVLM.Keywords: glutamate; hypertension; kynurenic acid; sarthran
Document Type: Research article
DOI: 10.1046/j.1440-1681.2002.03663.x
Affiliations: 1: Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA and 2: Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
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