Glutamate Circuits In Selected Medullo-Spinal Areas Regulating Cardiovascular Function

Author: Sapru, HN¹

Source: Clinical and Experimental Pharmacology and Physiology, Volume 29, Numbers 5-6, May/June 2002 , pp. 491-496(6)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

1. The importance of the medullo-spinal neuronal pools in the regulation of cardiovascular function has been known for a long time. However, important groups of these neurons, interconnections between them and the neurotransmitters released at their projections have been identified with certainty only during the past two decades.

2. Some of the medullo-spinal neuronal pools mediating cardiovascular function include the nucleus tractus solitarius, caudal ventrolateral medullary depressor area, rostral ventrolateral medullary pressor area, nucleus ambiguus and intermediolateral cell column of the thoracolumbar spinal cord. Interactions between these selected neuronal groups and neurotransmitters in the pathways connecting them are discussed in the present short review.

Keywords: blood pressure; bradycardia; caudal ventrolateral medulla; chemoreceptor projection site; depressor responses; heart rate; nucleus tractus solitarius; pressor responses; rostral ventrolateral medulla

Document Type: Research article

DOI: 10.1046/j.1440-1681.2002.03661.x

Affiliations: 1: Department of Neurosurgery, New Jersey Medical School, Newark, New Jersey, USA

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