IngentaConnect Angiotensin At1 Receptor Signalling Pathways In Neurons

Authors: Sumners, Colin¹; Fleegal, Melissa A¹; Zhu, Mingyan¹

Source: Clinical and Experimental Pharmacology and Physiology, Volume 29, Numbers 5-6, May/June 2002 , pp. 483-490(8)

Publisher: Blackwell Publishing

Abstract:

SUMMARY

1. The aim of the present article is to review the intracellular signal transduction pathways that are influenced by the peptide angiotensin (Ang) II, acting via its type 1 (AT₁) receptor, in neurons.

2. The AT₁ receptors couple to a wide variety of signalling pathways in peripheral tissues, such as kidney, heart and vascular smooth muscle. A similar diversity of signalling mechanisms exists for AT₁ receptors in neurons.

3. We outline the known neuronal AT₁ receptor signalling pathways as they relate to function. Pathways that couple activation of AT₁ receptors to short-term changes in neuronal membrane ionic currents and firing rate will be reviewed. These are different from the pathways that elicit longer-term changes in enzyme activity and gene expression and, ultimately, increases in noradrenaline synthesis.

4. Novel AT₁ receptor signalling pathways discovered through gene expression profiling and their potential functional significance have been discussed.

Keywords: angiotensin II; AT1 receptor; brain; G-proteins; ion channels; neuron; noradrenaline; signal transduction

Document Type: Research article

DOI: 10.1046/j.1440-1681.2002.03660.x

Affiliations: 1: Department of Physiology, College of Medicine and McKnight Brain Institute, University of Florida, Gainesville, Florida, USA

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax Refund Policy