Effect Of Kad-1229, A Novel Hypoglycaemic Agent, On Plasma Glucose Levels After Meal Load In Type 2 Diabetic Rats

Authors: Ichikawa, Kiyoshi¹; Yamato, Tokuhisa¹; Ojima, Kazuma¹; Tsuji, Atsutoshi¹; Ishikawa, Kohtaro¹; Kusama, Hiroshi¹; Kojima, Masami¹

Source: Clinical and Experimental Pharmacology and Physiology, Volume 29, Numbers 5-6, May/June 2002 , pp. 423-427(5)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

1. The effects of KAD-1229 (a novel non-sulphonylurea agent), voglibose (an α-glucosidase inhibitor) and nateglinide (a non-sulphonylurea antihyperglycaemic agent) on hyperglycaemia induced by a meal load were assessed in diabetic rats.

2. KAD-1229 suppressed the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUC_glucose) up to 5 h after the meal load.

3. Voglibose also suppressed the increase in plasma glucose levels; however, a significant decrease in AUC_glucose following voglibose was not observed.

4. Nateglinide suppressed the increase in plasma glucose levels at 30 min and 1 h after the meal load; however, plasma glucose levels was above control thereafter and the AUC_glucose was not decreased.

5. The results indicate that KAD-1229 has an antihyperglycaemic effect and KAD-1229 is suggested to be a suitable agent for controlling post-prandial hyperglycaemia.

Keywords: KAD-1229; meal load; nateglinide; plasma glucose level; plasma insulin; rats; type 2 diabetes; voglibose

Document Type: Research article

DOI: 10.1046/j.1440-1681.2002.03682.x

Affiliations: 1: Pharmacology Laboratories, Kissei Pharmaceutical Co. Ltd, Hotaka, Nagano, Japan

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