Effects Of Molybdenum, Silicon And Nickel On α1-Adrenoceptor-Induced Constriction Of Rat Isolated Aorta
Authors: Liu, Dong Ling1; Yan, Ming1; Chua, Yeow Leng1; Chen, Chen2; Lim, Yean Leng1
Source: Clinical and Experimental Pharmacology and Physiology, Volume 29, Numbers 5-6, May/June 2002 , pp. 395-398(4)
Publisher: Blackwell Publishing
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Abstract:
SUMMARY 1. To determine the effects of trace elements on α1-adrenoceptor-mediated vasoconstriction, we studied the effects of molybdenum (Mo), silicon (Si) and nickel (Ni) on vasoconstrictor response to an α1-adrenoceptor agonist in rat aorta. 2. Cumulative concentration-contraction curves were obtained for phenylephrine (1 nmol/L-10 μmol/L) in the absence and presence of Mo, Si and Ni (0.3, 1 and 3 μmol/L) in rat aorta rings. Increasing the concentration of Mo and Si from 0.3 to 3 μmol/L shifted the cumulative concentration-contraction curve to the right, but did not reduce the maximal contractile response to phenylephrine. In contrast, Ni at 1 and 3 μmol/L shifted the cumulative concentration-contraction curve to the right and, at 3 μmol/L, reduced the maximum contractile response to phenylephrine. 3. We conclude that micromolar concentrations of Mo, Si and Ni affected α1-adrenoceptor-induced vasoconstriction and that Ni significantly inhibited the maximal contractile response to phenylephrine in rat isolated aorta.Keywords: α1-adrenoceptor; molybdenum; nickel; silicon; rat aorta
Document Type: Research article
DOI: 10.1046/j.1440-1681.2002.03674.x
Affiliations: 1: Cardiac Research Laboratory, National Heart Centre of Singapore, Singapore and 2: Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
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