Proceedings of the Australian Physiological and Pharmacological Society Symposium: The Hypothalamus LEPTIN AND THE REGULATION OF FOOD INTAKE AND THE NEUROENDOCRINE AXIS IN SHEEP

Authors: Clarke, Iain J¹; Henry, Belinda¹; Iqbal, Javed¹; Goding, James W

Source: Clinical and Experimental Pharmacology and Physiology, Volume 28, Numbers 1-2, January/February 2001 , pp. 106-107(2)

Publisher: Blackwell Publishing

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

SUMMARY

1. Leptin is secreted by fat and acts on the brain.

2. Central infusion of leptin reduces food intake but does not alter endocrine secretions in normally fed sheep.

3. Leptin treatment can correct for altered hormonal secretion in fasted animals.

4. Alterations in bodyweight (leptin status) affect the expression of a number of genes in the hypothalamus that are involved in the regulation of food intake and neuroendocrine function.

5. Leptin receptors are found in both the hypothalamus and pituitary and direct action of leptin can be demonstrated on the somatotrophs in the pituitary.

Keywords: growth hormone; hypothalamus; leptin; luteinizing hormone; neuropeptide Y; obesity; pituitary

Document Type: Research article

DOI: 10.1046/j.1440-1681.2001.03410.x

Affiliations: 1: Prince Henry's Institute of Medical Research, Clayton and

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax Refund Policy