IngentaConnect Protective Effect Of Resveratrol On Oxidative Damage In Male And ...

Authors: Mizutani, Kenichi¹; Ikeda, Katsumi; Kawai, Yasuhiro; Yamori, Yukio¹

Source: Clinical and Experimental Pharmacology and Physiology, Volume 28, Numbers 1-2, January/February 2001 , pp. 55-59(5)

Publisher: Blackwell Publishing

Abstract:

SUMMARY

1. In the present study, we examined the effect of resveratrol (3,4′,5-trihydroxystilbene), a phytoestrogen found in the skins of most grapes, on oxidative DNA damage in male and female stroke-prone spontaneously hypertensive rats (SHRSP).

2. Five-week-old male and female SHRSP were divided into control and resveratrol groups. The resveratrol group was given 1 mg/kg per day, orally, resveratrol by gastric intubation once a day.

3. Following an 8 week feeding period, the levels of 8-hydroxydeoxyguanosine (8-OHdG), produced from deoxyguanosine under conditions of oxidative stress, in the urine of male and female resveratrol-treated SHRSP were significantly lower than that in control SHRSP.

4. The urine of resveratrol-treated male and female SHRSP had lower levels of hydroperoxide compared with control SHRSP, but the difference was not significant.

5. Treatment with resveratrol resulted in a 25 and 30% reduction in plasma glycated albumin in male and female SHRSP, respectively, compared with controls.

6. Gender differences for SHRSP with regard to 8-OHdG, hydroperoxide and glycated albumin levels were not confirmed, resveratrol having similar protective effects on male and female SHRSP.

7. These results indicate that dietary resveratrol: (i) plays a role in suppressing oxidative DNA damage and glycoxidative stress in vivo; and (ii) has similar protective effects in both male and female SHRSP, suggesting that the direct effects of this phytoestrogen on oxidative stress in vivo are not sexually dimorphic.

Keywords: advanced glycation end-products; oxidative stress; phytoestrogen; resveratrol; stroke-prone spontaneously hypertensive rats

Document Type: Research article

DOI: 10.1046/j.1440-1681.2001.03415.x

Affiliations: 1: Life Science, Environmental Conservation and Development,

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Protective Effect Of Resveratrol On Oxidative Damage In Male And Female Stroke-Prone Spontaneously Hypertensive Rats