Circumventricular Organs: Gateways to the Brain Subcellular Mechanisms Of Area Postrema Activation

Author: Hay, Meredith

Source: Clinical and Experimental Pharmacology and Physiology, Volume 28, Number 7, July 2001 , pp. 551-557(7)

Publisher: Blackwell Publishing

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Abstract:

SUMMARY

1. The present paper reviews some of the recent studies regarding the cellular mechanims regulating area postrema (AP) neuronal activity.

2. The calcium currents involved in activation and regulation of AP neuronal activity most likely belong to the Q- and R-family of calcium channels.

3. Angiotensin II increases AP activity by facilitating inward calcium currents and inhibiting calcium-activated potassium currents.

4. The heterogeneity observed regarding responsiveness to glutamate and 5-hydroxytryptamine and peptides may reflect multiple populations of AP neurons, each with specific roles in the integration of afferent and peptidergic neurotransmission.

Keywords: area postrema; calcium channels; cardiovascular regulation; neurotransmission; peptides

Document Type: Research article

DOI: 10.1046/j.1440-1681.2001.03486.x

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