IngentaConnect Effects of a non-steroidal (ketorolac tromethamine) and a steroid...

Authors: Luu, Chi D; Foo, Hayley; Crewther, Sheila G; Crewther, David P

Source: Clinical & Experimental Ophthalmology, Volume 29, Number 3, June 2001 , pp. 175-178(4)

Abstract:

Topical steroidal anti-inflammatory drugs (SAID) and non-steroidal anti-inflammatory drugs (NSAID) are known to affect fluid balance. The effects of twice daily topical applications of Maxidex (dexamethasone, a SAID), Acular (ketorolac, a NSAID), and saline were examined biometrically on the development of refractive errors and eye growth in chicks raised from days 3-12 wearing either a monocular +10 D, 0 D, or -10 D lens. Biometric analysis showed that neither SAID nor NSAID nor saline affected refractive error compensation but that the anti-inflammatory drugs affected eye growth. In chicks reared with a +10 D lens, dexamethasone induced a decrease in axial length (AL), vitreous chamber (VC) and anterior chamber (AC) depth, while ketorolac only induced a decrease in AC. In -10 D lens chicks dexamethasone again induced a decrease in AL and VC, but did not affect AC depth, whereas ketorolac only induced an increase in AC depth. Taken together, these results suggest that anti-inflammatory drugs can induce changes in ocular size without affecting refractive state and, as such, have implications for the management of progressive myopia.

Keywords: dexamethasone; ketorolac; non-steroidal anti-inflammatory drugs; ocular growth; refractive error

Document Type: Research article

DOI: 10.1046/j.1442-9071.2001.00400.x

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Effects of a non-steroidal (ketorolac tromethamine) and a steroidal (dexamethasone) anti-inflammatory drug on refractive state and ocular growth