IngentaConnect Neonatal leptin levels are strongly associated with female gender...

Authors: Petridou, Eleni; Mantzoros, Christos S.¹; Belechri, Maria²; Skalkidou, Alkistis²; Dessypris, Nick²; Papathoma, Eugenia³; Salvanos, Heraklis⁴; Lee, Jennifer H.¹; Kedikoglou, Simeon²; Chrousos, George; Trichopoulos, Dimitrios

Source: Clinical Endocrinology, Volume 62, Number 3, March 2005 , pp. 366-371(6)

Publisher: Blackwell Publishing

Abstract:

Summary Objective

To investigate predictors of circulating leptin in healthy full-term newborns and to explore the relationship with anthropometric variables, serum levels of adiponectin and the major components of the IGF system at birth. To explore whether leptin levels are regulated by breastfeeding vs. formula feeding. Design

Observational cross-sectional study. Patients

Three hundred and nineteen healthy full-term newborns delivered during 1999 in Athens, Greece. Measurements

Anthropometric measurements, formula feeding information and blood samples were obtained. Leptin and adiponectin determinations were performed using a radioimmunoassay (RIA). Results

Multivariate regression analyses showed that leptin levels were positively associated with female gender, newborn length, ponderal index and IGF-I levels, but not with adiponectin levels. Newborns who were fed exclusively with milk formulas had more than twice the leptin levels of those who were exclusively breastfed. Conclusions

Leptin levels are positively related to female gender and anthropometric characteristics of neonates but, contrary to studies in adults, are not correlated with adiponectin levels. We also found evidence that formula feeding imparts a considerable increase in leptin levels in newborns.

Document Type: Research article

DOI: 10.1111/j.1365-2265.2005.02225.x

Affiliations: 1: Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA, 2: Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece, 3: Department of Neonatology, ‘Alexandra’ Maternity Hospital, Athens, Greece, 4: Department of Neonatology, ‘Elena's Venizelou’ Maternity Hospital, Athens, Greece,

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Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding