IngentaConnect CD4 and CD8 Tlymphocyte regeneration after anti-retroviral therap...

Authors: Franco, J. M.¹; León-Leal, J. A.²; Leal, M.¹; Cano-Rodriguez, A.³; Pineda, J. A.¹; Macías, J.¹; Rubio, A.¹; Rey, C.⁴; Sanchez, B.⁵; Lissen, E.¹

Source: Clinical & Experimental Immunology, Volume 119, Number 3, March 2000 , pp. 493-498(6)

Publisher: Blackwell Publishing

Abstract:

Previous studies have shown a slow recovery of naive CD4⁺ T cell counts after anti-retroviral therapy in HIV-1-infected adults, which is in accordance with thymus atrophy after puberty. Here we investigate whether or not different patterns of naive CD4⁺ and CD8⁺ T cell repopulation are present in adult and child patients undergoing anti-retroviral treatment. Thus, 25 adults under highly active anti-retroviral therapy and 10 children under combined anti-retroviral therapy were retrospectively analysed for T cell subpopulations at baseline (T0) and around week 12 (T1) and week 24 (T2) of anti-retroviral treatment. Mean serum HIV-1 RNA levels dropped in both groups. Recovery of T cells in adults was characterized by a heterogeneous response between patients, with only 44% of them increasing their naive CD4⁺ and CD8⁺ T cell counts at T1, and changes in mean total CD4⁺ T cells were mainly shaped by memory cells. Otherwise, children were characterized by an early increase in naive T cells. Thus, at T1, all children analysed had a strong rise in CD4⁺ (from 389 ± 116 to 569 ± 121 cells/μl; P < 0·01), and nine out of 10 also in naive CD8⁺ T cells (from 244 ± 58 to 473 ± 85 cells/μl; P < 0·05). However, no significant correlation between age and naive repopulation was observed (P= 0·22) in children. Thus, children had the earlier and greater increases in naive T cell subsets than adults, probably due to a more active thymus, with the potential for immune reconstitution when HIV-1 replication is controlled.

Keywords: anti-retroviral therapy; immune reconstitution; naive; children; HIV

Document Type: Research article

DOI: 10.1046/j.1365-2249.2000.01152.x

Affiliations: 1: Viral Hepatitis and AIDS Study Group, and Departments of 2: Paediatrics, 3: Radiology, 4: Biochemistry and 5: Immunology, Virgen del Rocío University Hospital, Seville, Spain

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CD4+ and CD8+ T lymphocyte regeneration after anti-retroviral therapy in HIV-1-infected children and adult patients

CD4⁺ and CD8⁺ T lymphocyte regeneration after anti-retroviral therapy in HIV-1-infected children and adult patients