IngentaConnect Circulating CD4CD8 T lymphocytes in patients with Kawasaki diseas...

Authors: Hirao¹; Sugita²

Source: Clinical & Experimental Immunology, Volume 111, Number 2, February 1998 , pp. 397-401(5)

Abstract:

We serially monitored cell surface antigen expression on mononuclear cells in peripheral blood isolated from patients with Kawasaki disease (KD), and found, for the first time, that a markedly increased number of CD4⁺CD8⁺ T lymphocytes was present in some of the patients (11 of the 24 cases). The cases of five of these 11 patients were complicated with coronary artery lesion (CAL); the 13 patients with normal numbers of CD4⁺CD8⁺ T lymphocytes did not have CAL. The patients' age, sex and grade of systemic inflammation evaluated by peripheral leucocyte count and serum C-reactive protein levels were not correlated to the number of CD4⁺CD8⁺ T lymphocytes. Other cell surface antigen characteristics of the CD4⁺CD8⁺ T lymphocytes included CD3⁺, CD45RA⁺, CD45RO⁺, CD16⁻, and HLA-DR⁺. These results indicate that the surface antigen characteristics of the KD peripheral blood examined were the same as those of Epstein-Barr virus infection without CD45RA⁺. These findings provide useful information for the analysis of the pathogenesis of KD.

Keywords: Kawasaki disease; CD4+CD8+ T lymphocyte

Document Type: Original article

DOI: 10.1046/j.1365-2249.1998.00480.x

Affiliations: 1: First, 2: Second Departments of Paediatrics, Dokkyo University School of Medicine, Tochigi, Japan

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Circulating CD4+CD8+ T lymphocytes in patients with Kawasaki disease

Circulating CD4⁺CD8⁺ T lymphocytes in patients with Kawasaki disease