IngentaConnect Immunohistology of the early course of lentivirus-induced arthrit...

Authors: Von Bodungen,¹; Lechner¹; Pfister¹; Vogt¹; Cheevers²; Bertoni¹; Jungi¹; Peterhans¹

Source: Clinical & Experimental Immunology, Volume 111, Number 2, February 1998 , pp. 384-390(7)

Abstract:

Caprine arthritis encephalitis (CAE) is a lentiviral infection of goats characterized by mononuclear cell infiltration of various tissues, most prominently the joints, mammary glands and, in young animals, the brain. We have investigated the early stages of arthritis induced by intracarpal and intravenous infection with molecularly cloned CAE virus. Analysis of the synovial membranes by immunohistological methods showed that the proportion of CD8⁺T cells peaked around day 12 post-infection. CD4⁺ T cells increased to a lesser degree. The relative proportion of B cells rose steadily post-infection. At 33 days post-infection, plasma cells accounted for over one third of all inflammatory cells in the inflamed synovium. Histopathologically, the arthritic lesions in the synovial membranes closely resembled those in membranes of animals with a 2-year history of chronic arthritis. Our observations indicate that this type of short-term experimental infection is particularly suitable for studying the pathogenesis of goat lentiviral infection. In addition, our observations support the view that a predominantly humoral (type 2) immune response may contribute to the pathogenesis of CAE.

Keywords: caprine arthritis encephalitis virus; immunopathogenesis; rheumatoid arthritis; T cells; B cells; macrophages

Document Type: Original article

DOI: 10.1046/j.1365-2249.1998.00472.x

Affiliations: 1: Institute of Veterinary Virology, University of Bern, Bern, Switzerland, 2: Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA

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Immunohistology of the early course of lentivirus-induced arthritis