Free Content Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti-inflammatory role

Authors: Arai1; Yamamura1; Seki2; Hanyu1; Takahashi1; Abo3

Source: Clinical & Experimental Immunology, Volume 111, Number 2, February 1998 , pp. 345-352(8)

Publisher: Blackwell Publishing

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

The distribution of CD57+ T and CD56+ T cells in patients with RA was examined. In control osteoarthritis patients, these cells exist as a minor population in the peripheral blood. Our data show that in patients with RA, CD57+ T cell levels are elevated in peripheral blood, knee joint fluid, knee synovial membrane and bone marrow (BM), compared with peripheral blood of controls. CD57+ T cells are especially high in knee joint fluid and joint-adjacent BM, while CD56+ T cells show no such increase. CD57+ T cells contain a major population of CD8+ cells and higher proportions of CD4−8− cells and γδ T cells than do CD57−T cells. CD57+T cells in peripheral blood and joint fluid increase with the duration of disease. Erythrocyte sedimentation rate (ESR) is inversely correlated with the proportion of CD57+T cells in the joint fluid. Although RA frequently occurrs in patients with CD3+57+ cell leukaemia, and some CD57+T cells are likely to be involved in the onset of RA, we suggest that CD57+T cells may rather suppress inflammation of RA, and other cellular components (e. g. granulocytes) may govern the severity of the inflammation of RA. These CD57+ T cells are probably generated extrathymically in the adjacent BM or joint space.

Keywords: rheumatoid arthritis; CD3+ CD57+ T cells; joint fluid; joint-adjacent bone marrow; erythrocyte sedimentation rate

Document Type: Original article

DOI: 10.1046/j.1365-2249.1998.00511.x

Affiliations: 1: Departments of Orthopaedic Surgery, 2: Division of Basic Traumatology, National Defence Medical College Research Institute, Namiki, Tokorozawa, Japan 3: Immunology, Niigata University School of Medicine, Niigata,

You have access to the full text article on a website external to Ingentaconnect.

Please click here to view this article on InterScience.

You may be required to register and activate access on InterScience before you can obtain the full text. If you have any queries please contact onlinehelp@oxon.blackwellpublishing.com

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A