IngentaConnect Serum antibodies to HIV-1 are produced post-measles virus infecti...

Authors: Baskar¹; Collins¹; Dorsey-Cooper¹; Pyle¹; Nagel¹; Dwyer²; Dunston³; Johnson⁴; Kendig¹; Israel²; Nalin⁵; Adler¹

Source: Clinical & Experimental Immunology, Volume 111, Number 2, February 1998 , pp. 251-256(6)

Publisher: Blackwell Publishing

Abstract:

Convalescent sera obtained from patients who were recently recovered from an acute measles virus infection were tested for the presence of anti-HIV-1 antibodies by Western blot analysis. While 16% (17/104) of control sera displayed reactive bands to a variety of HIV proteins, 62% (45/73) of convalescent sera demonstrated immunoreactive bands corresponding to HIV-1 Pol and Gag, but not Env antigens. This cross-reactivity appears to be the result of an active measles infection. No HIV-1 immunoblot reactivity (0/10) was observed in sera obtained from young adults several weeks after a combined measles, mumps, and rubella (MMR) vaccination. Interestingly, examination of anti-HLA typing sera specific for either class I and class II molecules revealed that 46% (19/41) of these sera contained cross-reactive antibodies to HIV-1 proteins. Absorption of measles sera with mixed lymphocyte reaction (MLR)-activated lymphocytes and/or HIV-1 recombinant proteins significantly decreased or removed the presence of these HIV-1-immunoreactive antibodies. Together, these findings suggest that the immune response to a natural measles virus infection results in the production of antibodies to HIV-1 and possibly autoantigens.

Keywords: HIV-1; measles; indeterminate Western blot

Document Type: Original article

DOI: 10.1046/j.1365-2249.1998.00488.x

Affiliations: 1: Laboratory of Immunology, National Institute on Aging, NIH, 2: Maryland State Health Department, Baltimore, MD, 3: Howard University School of Medicine, Washington, DC, 4: Case Western Reserve University School of Medicine, Cleveland OH, 5: Merck Research Laboratories, West Point, PA, USA

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Serum antibodies to HIV-1 are produced post-measles virus infection: evidence for cross-reactivity with HLA