IngentaConnect Malignant melanoma in Chile: an unusual distribution of primary s...

Authors: Zemelman, V.¹; Roa, J.²; Tagle, S. Ruiz; Valenzuela, C. Y.³

Source: Clinical & Experimental Dermatology, Volume 31, Number 3, May 2006 , pp. 335-338(4)

Abstract:

Summary Background.

Mortality from malignant melanoma (MM) has increased in Chile in the past decade. The location of MM lesions on the body has been correlated with prognosis and survival.

Aim. To review body site and gender relationships with histopathologically confirmed primary MM in Chile. Methods.

Records of 575 cases presenting to 5 state hospitals from 1992 to 2001 were analysed. Results.

There were 360 women and 215 men. Women showed a significantly higher number of MM on the legs, cheeks and arms, and in the genital area, whereas men showed a significantly higher number on the ears, backs of the hands, soles and feet. Men had a predilection for MM with a poor prognosis. Conclusion.

The different body site distribution of primary MM in men and women may be explained by a different pattern of sun exposure. Ethnic and genetic factors may also be involved. The predominant location of MM in women in Chile is similar to white populations, whereas the location in men is similar to that observed in black and Asian populations. These observations may be relevant to the high mortality of MM in Chilean men.

Document Type: Research article

DOI: 10.1111/j.1365-2230.2005.02038.x

Affiliations: 1: Department of Dermatology, Clinical Hospital, University of Chile; Santiago, Chile 2: Postgraduate Department, Faculty of Medicine, University of Chile, Santiago, Chile 3: ‡Human Genetics Program, Faculty of Medicine, University of Chile, Santiago, Chile

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Malignant melanoma in Chile: an unusual distribution of primary sites in men from low socioeconomic strata