Vitiligo with inflammatory raised borders, associated with atopic dermatitis

Authors: Sugita, K.; Izu, K.; Tokura, Y.

Source: Clinical & Experimental Dermatology, Volume 31, Number 1, January 2006 , pp. 80-82(3)

Publisher: Blackwell Publishing

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Abstract:

Summary

A 31-year-old man had had atopic dermatitis since childhood and developed vitiligo with inflammatory raised borders 5 years prior to presentation. Immunohistochemically, CD4+ T cells infiltrated predominantly in the raised border of vitiligo, while CD8+ T cells were present just outside of the borders, suggesting that CD8+ cells were an antecedent to the CD4+ cells. Despite the presence of atopic dermatitis, the percentage of CXCR3+ CD4+ Th1 cells increased in the patient's peripheral blood, compared with a representative atopic patient showing a high percentage of CCR4+CD4+ Th2 cells. This case suggests that vitiligo with inflammatory raised borders can occur even in patients with atopic dermatitis when Th1 cells are activated and overcome the Th2-dominant state.

Document Type: Research article

DOI: 10.1111/j.1365-2230.2005.01987.x

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