Epidermolysis bullosa acquisita: diagnosis by fluorescence overlay antigen mapping and clinical response to high-dose intravenous immunoglobulin

Authors: Campos, M.; Silvente, C.; Lecona, Manuel¹; Suárez, R.; Lázaro, P.

Source: Clinical & Experimental Dermatology, Volume 31, Number 1, January 2006 , pp. 71-73(3)

Publisher: Blackwell Publishing

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Abstract:

Summary

Epidermolysis bullosa acquisita (EBA) is a chronic, subepidermal blistering disease characterized by the presence of autoantibodies to type VII collagen, located below the lamina densa of the basement membrane zone (BMZ) . There is a large clinical and histological overlap between EBA and other subepidermal autoimmune bullous diseases, therefore, complex immunological techniques are required to make an accurate diagnosis. Therapy of EBA is also a difficult issue. Most patients do not respond to several common immunosuppressive agents. We describe a patient who has shown a good response to high-dose intravenous immunoglobulin therapy.

Document Type: Research article

DOI: 10.1111/j.1365-2230.2005.01989.x

Affiliations: 1: Pathology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

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