A case of drug-induced hypersensitivity syndrome showing transient immunosuppression before viral reactivation during treatment for pemphigus foliaceus

Authors: Takahashi, H.; Tanaka, M.; Tanikawa, A.; Toyohara, A.¹; Ogo, Y.²; Morimoto, A.; Harato, R.; Kobayashi, M.; Amagai, M.

Source: Clinical & Experimental Dermatology, Volume 31, Number 1, January 2006 , pp. 33-35(3)

Publisher: Blackwell Publishing

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Abstract:

Summary

Drug–induced hypersensitivity syndrome (DIHS) is one of the most severe drug adverse reactions, with characteristic biphasic symptoms. Reactivation of human herpesvirus-6 (HHV-6) is frequently observed, although the cause of DIHS is still unknown. A patient developed DIHS during treatment with diaminodiphenylsulphone for pemphigus foliaceus. The number of lymphocytes in his peripheral blood, and titres of serum total IgG and IgM and anti-desmoglein1 antibody transiently decreased just before reactivation of HHV-6, cytomegalovirus and Epstein–Barr virus. This observation suggests that transient suppression of both cellular and humoral immunity may trigger viral reactivation, which leads to the development of the second phase of DIHS.

Document Type: Research article

DOI: 10.1111/j.1365-2230.2005.01913.x

Affiliations: 1: Kitasato Institute Hospital, Tokyo, Japan 2: OGO Skin Clinic, Tokyo, Japan

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