Transient leukaemia cutis in chronic lymphocytic leukaemia

Authors: WAKELIN, S.H.1; YOUNG, E.1; KELLY, S.2; TURNER, M.3

Source: Clinical & Experimental Dermatology, Volume 22, Number 1, January 1997 , pp. 37-40(4)

Publisher: Blackwell Publishing

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Abstract:

Leukaemia cutis arises due to cutaneous infiltration of neoplastic leukocytes or their precursors. Recent evidence suggests that this sign does not necessarily herald a poor prognosis.

We describe a 72-year-old woman with B-cell chronic lymphatic leukaemia (CLL) who developed a papular eruption on her breast at the site of a recent herpetic eruption. Histology and immunostaining showed a dense dermal B-cell infiltrate in keeping with leukaemia cutis. The papules cleared in 6 months without treatment, leaving atrophic scars. The histological features and possible aetiological mechanisms of post-herpetic papular eruptions in CLL are reviewed.

Document Type: Research article

DOI: 10.1046/j.1365-2230.1997.1890613.x

Affiliations: 1: Department of Dermatology, Amersham Hospital, Amersham, Bucks, UK, Departments of 2: Haematology, 3: Pathology, Wycombe General Hospital, Wycombe, Bucks, UK

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